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Takeda 6d

Chemical

C27H19ClFN5O3S

548.0

1125632-93-0

≥95%

Solid.

Soluble in DMSO.

Manufactured by SynKinase.

Target: B-RAF - VEGFR2 | Kinase Group: TKL | Substrate: Serine-ThreonineClick here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet.

MDPMAXSABUPRJI-UHFFFAOYSA-N

AMBIENT

+4°C

-20°C

Stable for at least 2 years after receipt when stored at -20°C.

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Takeda-6d has potent inhibitory activity in both B-RAF with an IC(50) of 7.0nM and VEGFR2 with an IC(50) of 2.2nM.Product References

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds: M. Okaniwa, et al.; J. Med. Chem. 55, 3452 (2012)

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