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Protein Jagged-1; CD339; JAG1

Monoclonal Antibody

J1G53-3

Mouse IgG1κ

Recombinant human Jagged-1.

FITC

Flow Cytometry: (1:20-1:100)Western blot: (1:500-1:5000 using ECL. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature).Optimal conditions should be determined individually for each application.

Human

Recognizes human Jagged-1. Detects a band of ~180kDa by Western blot.

Protein G-affinity purified.

1mg/ml

Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

BLUE ICE

+4°C

-20°C

After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.

Stable for at least 1 year after receipt when stored at -20°C.

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Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).Product References

Preclinical activity of the repurposed drug auranofin in classical Hodgkin lymphoma: M. Celegato, et al., Blood 126, 1394 (2015)

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