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Interleukin-33; IL-1F11; NF-HEV

Protein

E. coli

Human IL-33 (aa 112-270) is untagged.

HumanMouse

Binds to human and mouse ST2.

Activates human and mouse ST2-dependent NF-κB pathway.

~18kDa

≥95% (SDS-PAGE)

0.1mg/ml after reconstitution.

Reconstitute with 100μl sterile water.

Lyophilized. Contains PBS.

UniProt link Q2YEJ5: Interleukin-33 (human)

BLUE ICE

+4°C

-20°C

After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.PBS containing at least 0.1% BSA should be used for further dilutions.

Stable for at least 6 months after receipt when stored at -20°C.

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Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.Product References

An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor: M. Suzukawa, et al.; J. Immunol. 181, 5981 (2008)

Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils: M. Suzukawa, et al.; J. Immunol. 186, 5254 (2011)

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