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蚂蚁淘在线 / 品牌中心 / Adipogen品牌新闻

Adipogen/b-AP15 [DUB Inhibitor] Solution/AG-CS1-0102-M010/10 mg

作者： 时间：2024-11-10 点击量：

More Information Product Details Synonyms Product Type Properties Formula MW CAS Purity Chemicals Appearance Formulation Biological Activity Identity Declaration Other Product Data InChi Key Shipping and Handling Shipping Short Term Storage Long Term Storage Handling Advice Use/Stability Documents MSDS Product Specification Sheet Datasheet
VLX1500; NSC 687852
Chemical
C22H17N3O6
419.4
1009817-63-3
≥98% (HPLC)
Liquid.
10mM stock solution in DMSO.
Inhibits purified 19S deubiquitinase activity using Ub-AMC as substrate (in vitroIC50=2.1μM).Decreases HCT-116 cell viability at 72 hours (EC50=0.4μM).
Determined by 1H-NMR.
Manufactured by Boston Biochem
Note: May hydrolyze slowly in aqueous buffers.
GFARQYQBWJLZMW-JYFOCSDGSA-N
BLUE ICE
+4°C
-20°C
Avoid freeze/thaw cycles.
Stable for at least 6 months after receipt when stored at -20°C.
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  • Potent, reversible and cell-permeable inhibitor of the 19S deubiquitinases (DUBs) ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5).
  • Inhibitor of the 20S proteasome.
  • Anti-tumor compound.
Product References
  • Inhibition of proteasome deubiquitinating activity as a new cancer therapy: P. DArcy, et al.; Nat. Med. 17, 1636 (2011)
  • A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance: Z. Tian, et al.; Blood 123, 706 (2014)
  • The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death: X. Wang, et al.; Mol. Pharmacol. 85, 932 (2014)
  • Inhibitory effect of b-AP15 on the 20S proteasome: L. Huang, et al.; Biomolecules 4, 931 (2014)

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