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商品描述
| ProductDetails | |
|---|---|
| Synonyms | Autophagy-relatedProtein3;Ubiquitin-like-conjugatingEnzymeATG3;APG3-like;PC3-96 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | RecombinanthumanATG3(aa1-337)fusedtoaHis-tag. |
| Crossreactivity | Human |
| MW | ~37kDa(SDS-PAGE) |
| Purity | ≥95%(SDS-PAGE) |
| Concentration | 0.5mg/mlafterreconstitution. |
| Reconstitution | Reconstitutein100μlsterilewater.Forlongerstorageadditionof10%glycerolisrecommended. |
| Formulation | Lyophilizedfrom20mMTRIS-HCl,pH8.0,containing150mMsodiumchlorideandproteaseinhibitor(SigmaS8830,1xconcentration). |
| OtherProductData | NCBIReferenceNM_022488.3:ATG3(human) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
ATG3(Autophagy-relatedprotein3;APG3-like;PC3-96)isanubiquitousmemberoftheATG3familyofproteins.Itbelongstotheautophaginproteinfamilyimportantinautophagy,theBIOLOGicalprocesswhichisinvolvedindegradationofendogenousproteinsanddamagedorganelles.ATG3isanE2-likeenzymeinvolvedintheinitialstagesofautophagocytosis,autophagyandmitochondrialhomeostasis.Autophagocytosisisastarvation-inducedprocessresponsIBLeforthetransportofcytoplasmicproteinstothelysosome/vacuole.ItcatalyzesthetransferofATG7-boundATG8(LC3;GATE16;GABA-RAPinmammals)tophosphatidylethanolamine,whichisessentialforautophagy.ItactsasanautocatalyticE2-likeenzyme,catalyzingtheconjugationofATG12toitself.TheATG12conjugationtoATG3playsaroleinmitochondrialhomeostasisbutnotinautophagy.
