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4000-520-616 / 18915418616
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0512-67156496
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商品描述
| ProductDetails | |
|---|---|
| Synonyms | Fractalkine;Chemokine(C-X3-CMotif)Ligand1;Neurotactin;SCYD1 |
| ProductType | Protein |
| Properties | |
| Source/Host | HEK293cells |
| Sequence | TheextracellulardomainofhumanCX3CL1(aa25-339)isfusedattheC-terminustoaFLAG®-tag. |
| Crossreactivity | Human |
| MW | ~50kDa(SDS-PAGE) |
| Purity | ≥90%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstitute10µgvialwith100µlsterilewatertoaconcentrationof0.1mg/ml. Reconstitute50µgvialwith100µlsterilewatertoaconcentrationof0.5mg/ml. Add1XPBStothedesiredproteinconcentration. |
| AccessionNumber | AAH01163.1 |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | UniProtlinkAAH01163.1:CX3CL1(Fractalkine)(human) FLAGisaregisteredtrademarkofSigma-AldrichCo. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
CX3CL1[Fractalkine]isexpressedonTNF-αandIL-1activatedendothelialcells(ECs)andbindstoCX3CR1.CX3CL1canexistin2forms,asmembrane-anchoredorasashed95-kDaglycoprotein.ThesolubleCX3CL1haspotentchemoattractantactivityforTcellsandmonocytes,andthecellsurfaceboundprotein,whichisinducedonactivatedprimaryendothelialcells,promotesstrongadhesionofthoseleukocytes.CX3CL1mayplayaroleinregulatingleukocyteadhesionandmigrationprocessesattheendothelium.
