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商品描述
| ProductDetails | |
|---|---|
| Synonyms | GranulocyteColony-stimulatingFactor;G-CSF |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | TheextracellulardomainofmouseCSF3(aa31-208)isfusedtotheN-terminusoftheFcregionofmouseIgG2a. |
| Crossreactivity | Mouse |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstituteat100μg/mlinsterilePBS. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | NCBIreferenceCAA28986.1:CSF3(mouse) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
G-CSFisapleiotropiccytokinebestknownforitsspecificeffectsontheproliferation,differentiationandactivationofhematopoieticcellsoftheneutrophilicgranulocytelineage.Itisproducedmainlybymonocytesandmacrophagesuponactivationbyendotoxin,TNF-αandIFN-γ.Othercelltypesincludingfibroblasts,endothelialcells,astrocytesandbonemarrowstromalcellscanalsosecreteG-CSFafterLPS,IL-1orTNF-αactivation.Inaddition,variouscarcinomacelllinesandmyeloblasticleukemiacellscanexpressG-CSFconstitutively.G-CSFstimulatesgrowth,differentiationandfunctionsofcellsfromtheneutrophillineageinvitro.Consistentwithitsinvitrofunctions,G-CSFhasbeenfoundtoplayimportantrolesindefenseagainstinfection,ininflammationandrepairandinthemaintenanceofsteadystatehematopoiesis.RecombinanthumanG-CSFhasbeenapprovedfortheameliorationofchemotherapyinducedneutropeniaaswellasforseverechronicneutropeniafollowingmarrowtransplant.
