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蚂蚁淘在线 / 品牌中心 / Adipogen / Adipogen/CD54 [ICAM-1] (human):Fc (human) (rec.) (non-lytic)/CHI-HF-220ICAM1-C100/100 µg
商品描述
| ProductDetails | |
|---|---|
| Synonyms | ICAM1;IntercellularAdhesionMolecule1 |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | TheextracellulardomainofhumanCD54[ICAM-1](aa28-480)isfusedtotheN-terminusoftheFcregionofamutanthumanIgG1. |
| Crossreactivity | Human |
| BIOLOGicalActivity | ShowsthebiologicalfunctionoftheCD54moietyandexertsaprolongedcirculatinghalf-lifecausedbythemodifiedFcdomain. |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstituteat100μg/mlinsterilePBS. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | Non-lytic:Actsasalonglastingfusionproteinwhichonlybindstothereceptor.Mutationstothecomplement(C1q)andFcgRIbindingsitesoftheIgGsFcfragmentrenderthefusionproteinsincapableofantibodydirectedcytotoxicity(ADCC)andcomplementdirectedcytotoxicity(CDC). NCBIreferenceNP_000192.2:CD54(human) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
IntercellularAdhesionMolecule-1(ICAM-1,CD54)bindstheleukocyteintegrinsLFA-1andMac1.CD54expressionisweakonleukocytes,epithelialandrestingendothelialcells,aswellassomeothercelltypes,butexpressioncanbestimulatedbyIFN-γ,TNF-α,IL-1βandLPS.SolubleCD54isfoundinabiologicallyactiveforminserum,probablyasaresultofproteolyticcleavagefromthecellsurface,andiselevatedinpatientswithvariousinflammatorysyndromessuchassepticshock,LAD,cancerandtransplantation.
