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蚂蚁淘在线 / 品牌中心 / Adipogen / Adipogen/CD40L [CD154] (human):Fc (human) (rec.)/CHI-HF-210CD40L-C050/50 µg
商品描述
| ProductDetails | |
|---|---|
| Synonyms | CD154;TumorNecrosisFactorLigandSuperfamilyMember5;TNFSF5;Gp39 |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | TheextracellulardomainofhumanCD40L[CD154](aa113-261)isfusedtotheN-terminusoftheFcregionofhumanIgG1. |
| Crossreactivity | Human |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstitutein50µlsterilewater. Add1XPBStothedesiredproteinconcentration. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | NCBIreferenceNP_000065.1:CD40L(human) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
CD40Ligand(CD40L),renamedTNFSF5butnowalsoknownasCD154,TRAPandgp39,isa34-39kDatypeIItransmembraneglycoproteinthatbelongstotheTNFsuperfamily.AswithotherTNFsuperfamilymembers,CD40Lwillexistasatrimer,bothasamembraneboundandsolubleform.MultiplemutationsandalternatespliceformsofCD40Lexist,oftenassociatedwithpathologyandleADIngtotruncatedornontrimerizableformsofCD40L.CD40LbindstobothCD40andtointegrinαIIbβ3(CD41).Inthecellmembrane,italsoassociateswithauniquesplicevariantofCD28(CD28i)thatmayfacilitateCD40Lsignaltransduction.CD40Lisexpressedbymonocytes,NKcells,mastcells,basophils,smoothmusclecells,endothelialcells,dendriticcells,activatedandrestingBcells,plusactivatedplateletsandCD4+Tcells.CD40LligationofCD40ondendriticcells(DC)initiatesDCmaturationanddifferentiation.CD40LsignalingintonaiveBcellspromotesgerminalcenterformationandisotopeswitching.CD40-CD40Lseemstobridgeinnateandadaptiveimmunesignals.
