The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt"s lymphomas, suggesting its importance in the normal function of this gene.

Product Namec-Myc Polyclonal Antibodyc-Myc Rabbit pAbMRTL; MYCC; bHLHe39;c-Myc; MYC

Host Species Rabbit

Purification Method Affinity purification

IsotypeIgG

Storage/HandlingStore at -20℃.Avoid freeze / thaw cycles.

Storage BufferPBS with 0.02% sodium azide, 50%glycerol, pH7.3.

Immunogen Information

ImmunogenA synthetic peptide corresponding to a sequence within amino acids 1-100 of human c-Myc (NP_002458.2).

Sequence MDFFRVVENQ QPPATMPLNV SFTNRNYDLD YDSVQPYFYC DEEENFYQQQ QQSELQPPAP SEDIWKKFEL LPTPPLSPSR RSGLCSPSYV AVTPFSLRGD

Gene ID: 4609

Swiss Protein: P01106

Calculated MW: 48 kDa/50 kDa

Observed MW: 49 kDa

★活体技术荧光检测荧光蛋白标记适用于标记细胞、病毒、基因等，通常使用的是 GFP、EGFP、RFP（DsRed）等；荧光染料标记适用于标记抗体、多肽、小分子药物等；常用的有 Cy3、Cy5、Cy5.5 及 Cy7量子点标记（新的标记方法）适用于标记肿瘤，主要应用在活细胞实时动态荧光观察与成像；量子点（quantum dot) 是一种能发射荧光的半导体纳米微晶体，外观恰似一极小的点状物。量子点荧光比有机荧光染料的发射光强的 20 倍，稳定性强 100 倍以上，具有荧光发光光谱较窄、量子产率高、不易漂白、激发光谱宽、颜色可调，并且光化学稳定性高，不易分解等诸多优点。