Description

Halofuginone is a coccidiostat used in veterinary medicine. This synthetic enzyme inhibitor is derived from febrifugine, a quinazoline alkaloid isolated in Dichroa febrifuga. As a halogenated quinazoline derivative, Halofuginone contains a fused pair of aromatic rings, benzene and pyrimidine.

The chemical selectively regulates the autoimmune disease-promotive T helper 17 cell development.Halofuginone also controls cell migration, collagen type I synthesis and MMP-2 gene expression to inhibit proliferative tumor activity. In mice, Halofuginone has suppressed tumors and cancerous metastasis by functioning as a high-affinity inhibitor to glutamyl-prolyl tRNA synthetase. This inhibition induces anti-inflammatory and anti-fibrotic effects by means of the amino acid starvation response.

Medicinally, Halofuginone qualifies as an anti-inflammatory, antiprotozoal and anti-angiogenic agent. When fed to animals, it prevents coccidiosis. In studies of osteoarthritis, Halofuginone inhibited TGF-β activity and H-type vessel formation, attenuating the condition.

Product SpecificationsHalofuginone7-Bromo-6-chloro-3-{3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-quinazolinone7-bromo-6-chlorofebrifugineStenorol

Formula: C₁₆H₁₇BrClN₃O₃

MW: 414.68 g/mol

Storage/Handling: Store at room temperature.

PubChem Chemical ID:62891

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