GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
RecombinantHuman Neuregulin 1 Beta 2 (NRG1-β2)GlialGrowth FactorHeregulin-Alpha(HRGA)NEUDifferentiation Factor (NDF)AcetylcholineReceptor Inducing ActivityBreastCancer Cell Differentiation Factor p45Sensory andMotor Neuron-Derived Factor (SMDF)
Neuregulin 1 belongs to a family of structurally related polypeptide growth factors and is produced in numerous isoforms by alternative splicing, which allows it to perform a wide variety of functions. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They all have the EGF-like domain, and can bind to ErbB3 and ErbB4 receptor tyrosine kinases. This binding induces ErbB3 and ErbB4 heterodimerization with ErbB2, stimulating intrinsic kinase activity. This recombinant protein is the EGF-like domain (177-241 a.a.) of isoform 6, the major neuronal isoform. NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells. NRG1 is necessary for development, structural maintenance, and functional integrity of the heart. It is also thought to play a role in synaptic plasticity. Dysregulation of NRG1 has been linked to various cancers and schizophrenia.
Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.
Source: Escherichia coli
MW: ~7.5 kDa (65 aminoacids)
Purity: >97% by SDS-PAGEand HPLC analyses
Biological Activity: Fully biologicallyactive when compared to standard. The ED50 as determined by a cell proliferationassay using serum free human MCF-7 cells is less than 0.5 ng/ml, correspondingto a specific activity of >2.0×106 IU/mg.
Storage/Handling: Store desiccated at-20°C.
HGNC: 7997
NOT FOR HUMAN USE!
Additional resources for this protein may be found at:OMIMUniProt
★活体技术荧光检测荧光蛋白标记适用于标记细胞、病毒、基因等，通常使用的是 GFP、EGFP、RFP（DsRed）等；荧光染料标记适用于标记抗体、多肽、小分子药物等；常用的有 Cy3、Cy5、Cy5.5 及 Cy7量子点标记（新的标记方法）适用于标记肿瘤，主要应用在活细胞实时动态荧光观察与成像；量子点（quantum dot) 是一种能发射荧光的半导体纳米微晶体，外观恰似一极小的点状物。量子点荧光比有机荧光染料的发射光强的 20 倍，稳定性强 100 倍以上，具有荧光发光光谱较窄、量子产率高、不易漂白、激发光谱宽、颜色可调，并且光化学稳定性高，不易分解等诸多优点。
