ADIponectinELISAwithplateofadipocytes

Adipocytes(fatcells)expressavarietyofproteinsthatfunctioninthehomeostaticcontrolofglucoseandlipidmetabolism.Insulinregulatesthetranslocationandsecretionofmanyoftheseproteinsinresponsetochangesinenergybalance.Adipocytecomplement-relatedproteinof30kDa(Acrp30),nowknownasadiponectin,isaproteinwhosesecretionfromadipocytesisenhancedbyinsulinstimulation.

Ithasbeensuggestedthatthedevelopmentofnon-insulindependent(TypeII)diabetesmayinvolvedysregulationofadiponectinsecretion(1).InsupportofthelinkbetweenobesityandTypeIIdiabetes,ithasbeenshownthatdecreasedexpressionofadiponectincorrelateswithinsulinresistance(2,3),andthatadiponectinappearstobeapotentinsulinenhancerlinkingadiposetissueandwhole-bodyglucosemetabolism(4).

1. Nemet,D.,etal.(2002)Relationshipsamongadiponectinandotheradiposecytokines,bodycomposition,andfastinginsulininlowersocioeconomicmiddleschoolchildren.AmericanPhysiologicalSociety"s(APS)Abstracts.
2. YamauchiT.,etal.(2001)Thefat-derivedhormoneadiponectinreversesinsulinresistanceassociatedwithbothlipoatrophyandobesity.NatureMedicine,Aug;7(8):941-6
3. Kubota,N.,etal.(2002)Disruptionofadiponectincausesinsulinresistanceandneointimalformation.JBiolChem.277(29):25863-6(Epub2002May24).
4. BergA.H.,etal.(2001)Theadipocyte-secretedproteinAcrp30enhanceshepaticinsulinaction.NatureMedicine,Aug;7(8):947-53

ThishumanAdiponectinELISAkitisdesignedtomeasuretheconcentrationofhumanadiponectinfromhumanserum/plasma,humanadipocytes,orconditionedmedium.

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