Metabolic disease is associated more closely with the accumulation of abdominal adipose in specific visceral depots. Recent studies have implicated omental and mesenteric adipose tissue in obesity-related insulin resistance, atherosclerosis, and type 2 diabetes. To provide the most relevant systems for investigating obesity-related morbidities, ZenBio is offering visceral derived human preadipocytes and cultured adipocytes to the research community.
Preadipocytes are isolated from omental, mesenteric, or perirenal adipose tissue and are tested for their ability to differentiate in culture to mature adipocytes. Preadipocytes are available cryopreserved or plated and mature adipocytes are available in a variety of plated formats.
Most cells are derived from obese non-diabetic patients (BMI>30), but there are limited quantities of preadipocytes and adipocytes from patients of BMI <27 as well as some lots of cells available from diabetic patients. Lots derived from multiple patients are also available as Pooled- or Super-lots.
There are limited quantities of donor matched omental and subcutaneous preadipocytes or cultured adipocytes for studies comparing the two depots.
OMENTAL ADIPOSE
The greater omentum is the largest peritoneal fold within the abdomen and has an immunologic function. The omentum aids in isolating peritoneal infection and absorbing contaminants through the mesothelial stomata. Adipokines and fatty acids from this depot have direct access to the liver through the portal circulation which may lead to hepatic dysfunction.
MESENTERIC ADIPOSE
Mesenteric adipose lies within the thin layers of the peritoneal mesothelium connecting the small and large intestine. Adipose accumulation within this depot correlates with an increased risk of metabolic disease.
PERIRENAL ADIPOSE
Perirenal adipose resides near the kidneys outside the peritoneal cavity. Fat from this depot has not been correlated with increased risk for metabolic disease.
Specially formulated media are available for use with our omental preadipocytes and adipocytes.
enBio和COVID-19在Zen-Bio，员工和客户的健康和安全始终是我们的首要任务。目前，Zen-Bio已开放并在此时保持正常运行。我们将继续与客户合作，以满足他们的研究产品和合同服务的需求。Zen-Bio采取了多种措施来确保我们员工的安全并持续为我们的客户提供服务，其中包括：向所有员工加强适当的卫生技术限制访客进入和进入我们的设施增强日常清洁程序尽量减少员工之间不必要的联系，以鼓励社会疏远停止所有国内和国际旅行解决一个或多个员工受到该病毒影响的情况的应急计划
