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ProductName		ADisintegrinandMetalloprotease11(ADAM11),ELISAKit
AlsoKnownAs		PigeonADisintegrinandMetalloprotease11ELISAKit
ProductGeneName		ADAM11elisakit	[SimilarProducts]
ResearchUseOnly		ForResearchUseOnly.Notforuseindiagnosticprocedures.
RequestforManualInsert
OMIM		605007
3DStructure		ModBase3DStructureforQ9UNA0
SpeciesReactivity		Pigeon
PreparationandStorage		Storeallreagentsat2-8degreeC
ProductNote		OurELISAassaysaredynamicresearchtoolsandsometimestheymaybeupdatedandimproved.Iftheformatofthisassayisimportanttoyouthenpleasecontactourtechnicalsupportteamwithapresalesinquirybeforeplacinganorder.Wewillconfirmthecurrentdetailsoftheassay.
OtherNotes		SmallvolumesofADAM11elisakitvial(s)mayoccasionallybecomeentrappedinthesealoftheproductvialduringshipmentandstorage.Ifnecessary,brieflycentrifugethevialonatabletopcentrifugetodislodgeanyliquidinthecontainer`scap.Certainproductsmayrequiretoshipwithdryiceandadditionaldryicefeemayapply.
SearchableTermsforADAM11purchase		MBS067101isaready-to-usemicrowell,stripplateELISA(enzyme-linkedimmunosorbentassay)KitforanalyzingthepresenceoftheADisintegrinandMetalloprotease11(ADAM11)ELISAKittargetanalytesinBIOLOGicalsamples.TheconcentrationgrADIentsofthekitstandardsorpositivecontrolsrenderatheoreticalkitdetectionrangeinbiologicalresearchsamplescontainingADAM11.TheELISAanalyticalbiochemicaltechniqueoftheMBS067101kitisbasedonADAM11antibody-ADAM11antigeninteractions(immunosorbency)andanHRPcolorimetricdetectionsystemtodetectADAM11antigentargetsinsamples.TheELISAKitisdesignedtodetectnative,notrecombinant,ADAM11.Appropriatesampletypesmayincludeundilutedbodyfluidsand/ortissuehomogenates,secretions.Qualitycontrolassaysassessingreproducibilityidentifiedtheintra-assayCV(%)andinter-assayCV(%).
NCBI/UniprotdatabelowdescribegeneralgeneinformationforADAM11.Itmaynotnecessarilybeapplicabletothisproduct.
NCBIGI#		317373326
NCBIGeneID		11096
NCBIAccession#		Q9UNA0.2	[OtherProducts]
UniProtPrimaryAccession#		Q9UNA0	[OtherProducts]
UniProtSecondaryAccession#		Q52LV4;Q9UKP2	[OtherProducts]
UniProtRelatedAccession#		Q9UNA0	[OtherProducts]
MolecularWeight		101,718Da
NCBIOfficialFullName		Adisintegrinandmetalloproteinasewiththrombospondinmotifs5
NCBIOfficialSynonymFullNames		ADAMmetallopeptidasewiththrombospondintype1motif,5
NCBIOfficialSymbol		ADAMTS5	[SimilarProducts]
NCBIOfficialSynonymSymbols		ADMP-2;ADAM-TS5;ADAMTS-5;ADAMTS11;ADAM-TS5;ADAMTS-11;ADAM-TS11	[SimilarProducts]
NCBIProteinInformation		Adisintegrinandmetalloproteinasewiththrombospondinmotifs5;aggrecanase-2;adisintegrinandmetalloproteinasewiththrombospondinmotifs11;adisintegrin-likeandmetalloprotease(reprolysintype)withthrombospondintype1motif,5(aggrecanase-2)
UniProtProteinName		Adisintegrinandmetalloproteinasewiththrombospondinmotifs5
UniProtSynonymProteinNames		Adisintegrinandmetalloproteinasewiththrombospondinmotifs11;ADAM-TS11;ADAMTS-11;ADMP-2;Aggrecanase-2
ProteinFamily		Disintegrinandmetalloproteinasedomain-containingprotein
UniProtGeneName		ADAMTS5	[SimilarProducts]
UniProtSynonymGeneNames		ADAMTS11;ADMP2;ADAM-TS5;ADAM-TS5;ADAMTS-5;ADAM-TS11;ADAMTS-11	[SimilarProducts]
UniProtEntryName		ATS5_HUMAN
NCBISummaryforADAM11		ThisgeneencodesamemberoftheADAMTS(adisintegrinandmetalloproteinasewiththrombospondinmotifs)proteinfamily.Membersofthefamilyshareseveraldistinctproteinmodules,includingapropeptideregion,ametalloproteinasedomain,adisintegrin-likedomain,andathrombospondintype1(TS)motif.IndividualmembersofthisfamilydifferinthenumberofC-terminalTSmotifs,andsomehaveuniqueC-terminaldomains.TheenzymeencodedbythisgenecontainstwoC-terminalTSmotifsandfunctionsasaggrecanasetocleaveaggrecan,amajorproteoglycanofcartilage.[providedbyRefSeq,Jul2008]
UniProtCommentsforADAM11		ADAMTS5:Cleavesaggrecan,acartilageproteoglycan,andmaybeinvolvedinitsturnover.Mayplayanimportantroleinthedestructionofaggrecaninarthriticdiseases.Mayplayaroleinproteolyticprocessingmostlyduringtheperi-implantationperiod. Proteintype:Extracellularmatrix;Secreted,signalpeptide;Motility/polarity/chemotaxis;EC3.4.24.-;Protease;Secreted ChromosomalLocationofHumanOrtholog:21q21.3 CellularComponent:proteinaceousextracellularmatrix;endoplasmicreticulumlumen;extracellularregion MolecularFunction:integrinbinding;proteinbinding;metallopeptidaseactivity;zincionbinding;metalloendopeptidaseactivity BiologicalProcess:proteinaminoacidO-linkedglycosylation;extracellularmatrixdisassembly;extracellularmatrixorganizationandbiogenesis;cellularproteinmetabolicprocess;defenseresponsetobacterium;proteolysis;post-translationalproteinmodification
ResearchArticlesonADAM11		1.psiepsilonRACKinducedupregulationofhsa-miR-377expression,coupledtodecreasesinADAMTS5andcleavedaggrecan
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