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ProductName		ADisintegrinandMetalloprotease10(ADAM10),ELISAKit
AlsoKnownAs		CavyADisintegrinandMetalloprotease10ELISAKit
ProductGeneName		ADAM10elisakit	[SimilarProducts]
ResearchUseOnly		ForResearchUseOnly.Notforuseindiagnosticprocedures.
RequestforManualInsert
ChromosomeLocation		Chromosome:15;NC_000015.9(58888510..59042177,complement).Location:15q22
OMIM		602192
3DStructure		ModBase3DStructureforO14672
SpeciesReactivity		Cavy
AssayType		Sandwich
PreparationandStorage		Storeallreagentsat2-8degreeC
ProductNote		OurELISAassaysaredynamicresearchtoolsandsometimestheymaybeupdatedandimproved.Iftheformatofthisassayisimportanttoyouthenpleasecontactourtechnicalsupportteamwithapresalesinquirybeforeplacinganorder.Wewillconfirmthecurrentdetailsoftheassay.
OtherNotes		SmallvolumesofADAM10elisakitvial(s)mayoccasionallybecomeentrappedinthesealoftheproductvialduringshipmentandstorage.Ifnecessary,brieflycentrifugethevialonatabletopcentrifugetodislodgeanyliquidinthecontainer`scap.Certainproductsmayrequiretoshipwithdryiceandadditionaldryicefeemayapply.
SearchableTermsforADAM10purchase		MBS028786isaready-to-usemicrowell,stripplateSandwichELISA(enzyme-linkedimmunosorbentassay)KitforanalyzingthepresenceoftheADisintegrinandMetalloprotease10(ADAM10)ELISAKittargetanalytesinBIOLOGicalsamples.TheconcentrationgrADIentsofthekitstandardsorpositivecontrolsrenderatheoreticalkitdetectionrangeinbiologicalresearchsamplescontainingADAM10.TheELISAanalyticalbiochemicaltechniqueoftheMBS028786kitisbasedonADAM10antibody-ADAM10antigeninteractions(immunosorbency)andanHRPcolorimetricdetectionsystemtodetectADAM10antigentargetsinsamples.TheELISAKitisdesignedtodetectnative,notrecombinant,ADAM10.Appropriatesampletypesmayincludeundilutedbodyfluidsand/ortissuehomogenates,secretions.Qualitycontrolassaysassessingreproducibilityidentifiedtheintra-assayCV(%)andinter-assayCV(%).
NCBI/UniprotdatabelowdescribegeneralgeneinformationforADAM10.Itmaynotnecessarilybeapplicabletothisproduct.
NCBIGI#		2393947
NCBIGeneID		102
NCBIAccession#		AAC51766.1	[OtherProducts]
UniProtPrimaryAccession#		O14672	[OtherProducts]
UniProtSecondaryAccession#		Q10742;Q92650	[OtherProducts]
UniProtRelatedAccession#		O14672	[OtherProducts]
MolecularWeight		84,142Da
NCBIOfficialFullName		ADAM10
NCBIOfficialSynonymFullNames		ADAMmetallopeptidasedomain10
NCBIOfficialSymbol		ADAM10	[SimilarProducts]
NCBIOfficialSynonymSymbols		kuz;AD10;MADM;CD156c;HsT18717	[SimilarProducts]
NCBIProteinInformation		disintegrinandmetalloproteinasedomain-containingprotein10;CDw156;ADAM10;kuzbanianproteinhomolog;mammaliandisintegrin-metalloprotease;adisintegrinandmetalloproteasedomain10;adisintegrinandmetalloproteinasedomain10
UniProtProteinName		Disintegrinandmetalloproteinasedomain-containingprotein10
UniProtSynonymProteinNames		CDw156;Kuzbanianproteinhomolog;Mammaliandisintegrin-metalloprotease
ProteinFamily		Disintegrinandmetalloproteinasedomain-containingprotein
UniProtGeneName		ADAM10	[SimilarProducts]
UniProtSynonymGeneNames		KUZ;MADM;ADAM10	[SimilarProducts]
UniProtEntryName		ADA10_HUMAN
NCBISummaryforADAM10		MembersoftheADAMfamilyarecellsurfaceproteinswithauniquestructurepossessingbothpotentialadhesionandproteasedomains.ThisgeneencodesandADAMfamilymemberthatcleavesmanyproteinsincludingTNF-alphaandE-cadherin.[providedbyRefSeq,Jul2008]
UniProtCommentsforADAM10		ADAM10:Cleavesthemembrane-boundprecursorofTNF-alphaat'76-Ala-|-Val-77'toitsmaturesolubleform.ResponsIBLefortheproteolyticalreleaseofsolubleJAM3fromendothelialcellssurface.Responsiblefortheproteolyticreleaseofseveralothercell-surfaceproteins,includingheparin-bindingepidermalgrowth-likefactor,ephrin-A2andforconstitutiveandregulatedalpha-secretasecleavageofamyloidprecursorprotein(APP).Contributestothenormalcleavageofthecellularprionprotein.InvolvedinthecleavageoftheadhesionmoleculeL1atthecellsurfaceandinreleasedmembranevesicles,suggestingavesicle-basedproteaseactivity.ControlsalsotheproteolyticprocessingofNotchandmediateslateralinhibitionduringneurogenesis.ResponsiblefortheFasLectodomainsheddingandforthegenerationoftheremnantADAM10-processedFasL(FasLAPL)transmembraneform.AlsocleavestheectodomainoftheintegralmembraneproteinsCORINandITM2B.MayregulatetheEFNA5-EPHA3signaling. Proteintype:EC3.4.24.81;Motility/polarity/chemotaxis;Membraneprotein,integral;Cellsurface;Celladhesion;Vesicle;Protease ChromosomalLocationofHumanOrtholog:15q22 CellularComponent:Golgiapparatus;focaladhesion;cellsurface;membrane;intracellularmembrane-boundorganelle;postsynapticdensity;cytoplasm;plasmamembrane;integraltomembrane;Golgi-associatedvesicle;nucleus MolecularFunction:integrinbinding;proteinbinding;proteinhomodimerizationactivity;zincionbinding;metallopeptidaseactivity;metalloendopeptidaseactivity;endopeptidaseactivity;SH3domainbinding;proteinkinasebinding;receptorbinding BiologicalProcess:epidermalgrowthfactorreceptorsignalingpathway;integrin-mediatedsignalingpathway;axonguidance;extracellularmatrixorganizationandbiogenesis;Notchsignalingpathway;inuteroembryonicdevelopment;membraneproteinectodomainproteolysis;constitutiveproteinectodomainproteolysis;Notchreceptorprocessing;negativeregulationofcelladhesion;positiveregulationofcellgrowth;proteinaminoacidphosphorylation;extracellularmatrixdisassembly;collagencatabolicprocess;PMA-induciblemembraneproteinectodomainproteolysis;monocyteactivation;cell-cellsignaling;positiveregulationofcellproliferation;ephrinreceptorsignalingpathway;positiveregulationofcellmigration Disease:ReticulateAcropigmentationOfKitamura;AlzheimerDisease18
ResearchArticlesonADAM10		1.MiR-144andMir-451negativelyregulatortheADAM10proteinexpressionandmaycontributetoAlzheimerdiseasepathogenesis.
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