StressMarq蚂蚁淘在线

Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer	PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Storage Temperature	-20ºC
Shipping Temperature	Blue Ice or 4ºC
Purification	Affinity Purified
Clonality	Polyclonal
Isotype	IgG
Specificity	Detects endogenous levels of total ABCG2
Cite This Product	StressMarq Biosciences Cat# SPC-1317, RRID: AB_2713493
Certificate of Analysis	A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names	ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Cellular Localization	Cell membrane, Mitochondrion membrane
Accession Number	NP_004818.2
Gene ID	9429
Swiss Prot	Q9UNQ0
Scientific Background	ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
References	1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.

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ATTO 680

Overview:

High fluorescence yield
Excellent thermal and photostability
Quenched by electron donors
Very hydrophilic
Good solubility in polar solvents
Zwitterionic dye
Molar Mass: 631 g/mol

ATTO 680 Datasheet

ATTO 680 Fluorophore Absorption and Emission Spectrum

Optical Properties:

λ_ex = 680 nm

λ_em = 700 nm

ε_max = 1.25×10⁵

Φ_f = 0.30

τ_fl = 1.7 ns

Brightness = 37.5

Laser = 633 – 676 nm

Filter set = Cy®5.5

StressMarq细胞信号生物体中的每个细胞都暴露于来自其环境的数百种不同信号。单元可以以多种方式响应这些信号，并且独立地响应。但是，所有这些独立的动作在控制基本细胞活动的非常复杂且相互联系的通信路径中融合在一起。细胞外信号通过各种信号网络传输信息，最终在细胞核水平发挥作用。小区信令或蜂窝通信的三个阶段包括：接收信号信号转导单元内的响应倾向于起源于质膜水平的信号传导途径或网络包括G蛋白偶联受体，（非受体）酪氨酸激酶和离子调节通道等。尽管这些过程中涉及的关键调节分子有所不同，但信号的传输通常涉及一个共同的过程。靶蛋白的可逆磷酸化。两种不同的酶介导了这一点：蛋白激酶–磷酸化蛋白质（添加磷酸基团）蛋白质磷酸酶–使蛋白质脱磷酸（去除磷酸基团）细胞感知并正确响应其微环境的能力是发育，组织修复，免疫以及正常组织动态平衡的基础。细胞内信号传导事件实际上调节了所有细胞活动。细胞信息处理中的错误可能导致癌症，自身免疫性疾病和糖尿病等疾病。通过了解细胞信号传导的基本原理，研究人员希望能够开发出新药并对其进行选择性和有效治疗。细胞信号研究需要大量的生命科学产品。我们致力于开发最先进的研究产品，以协助研究细胞信号传导，包括单克隆抗体，多克隆抗体，抗体结合物，蛋白质，免疫测定法和小分子抑制剂。

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