Synaptotagmin-7MonoclonalAntibody

ORDERINGINFORMATIONCatalogNo.:56533(cloneS275-14)Size:100uginPBS(1mg/ml),pH7.4,50%glycerol,0.09%sodiumazide.

PurifiedbyProteinGaffinitychromatography.

BACKGROUND

SynaptotagminsconstituteafamilyofmembranetraffickingproteinsthatarecharacterizedbyanNterminaltrans-membraneregion(TMR),avariablelinker,andtwoC-terminalC2domains:C2AandC2B.Thereare15membersinthemammaliansynaptotagminfamily.

ThesynaptotagminsareintegralmembraneproteinsofsynapticvesiclesthoughttoactasCa+2sensorsinvesiculartraffickingandexocytosis.

Calciumbindingtosynaptotagmintriggersneurotransmitterreleaseatthesynapse.ThefirstC2domainmediatesCa+2-dependentphospholipidbinding.ThesecondC2domainmediatesinteractionwithStonin2.

SPECIFICATIONSUMMARYAntigen:Fusionproteincorrespondingtoaa150-239ofmouseSynapto-tagmin-7(accessionno.Q9R0N7).HostSpecies:MouseAntibodyClass:IgG2b

SPECIFICITY

ThisantibodyrecognizesmouseandratSynaptotagmin-7.Itdoesnotcross-reactwithotherSynaptotagmins.

APPLICATIONS

Immunoblotting:useat1ug/ml.Predictedmolecularweightis~45kDa.Otherisoformsof~65kDaarealsodetected.

Immunoblotonratbrainlysatewith#56533at1ug/ml.

PositiveControl:ratbrainlysate.

Thesearerecommendedconcentrations.Endusersshoulddetermineoptimalconcentrationsfortheirapplications.

DILUTIONINSTRUCTIONS

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

STORAGEANDSTABILITY

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notintendedfordiagnosticortherapeuticapplications.

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