mGluR1/5GlutamateReceptorMonoclonalAntibody

ORDERINGINFORMATION

CatalogNo.:56526(cloneS75-33)Size:100uginPBS(1mg/ml),pH7.4,50%glycerol,0.09%sodiumazide.

PurifiedbyProteinGaffinitychromatography.

BACKGROUND

Themetabotropicglutamatereceptors(mGluRs)areglutamatereceptorsthatareactivethroughanindirectmetabotropicprocess.TheyaremembersofthegroupCfamilyofG-protein-coupledreceptors(GPCRs).ThemGluRsperformavarietyoffunctionsinthecentralandperipheralnervoussystems.Theyarefoundinpre-andpostsynapticneuronsinsynapsesofthehippocampus,cerebellum,andthecerebralcortex,aswellasotherpartsofthebrainandinperipheraltissues.Unlikeionotropicreceptors,metabotropicglutamatereceptorsarenotionchannels.Instead,theyactivatebiochemicalcascades,leADIngtothemodificationofotherproteins.

SPECIFICATIONSUMMARY

Antigen:Fusionproteincorrespondingtoaa824-1203(cytoplasmicC-terminus)ofratmGluR5b(accessionno.

NP_058708.1).

HostSpecies:Mouse

AntibodyClass:IgG1

SPECIFICITY

Thisantibodyrecognizeshuman,mouse,andratmGluR1/5.

APPLICATIONS

Immunoblotting:useat1-2ug/ml.Abandof~130kDaisdetected.

Immunoblotonratbrainmembranes.

Immunohistochemistry:useat1-5ug/ml.Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.

Positivecontrol:Ratbrainmembranes.

DILUTIONINSTRUCTIONS

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

STORAGEANDSTABILITY

Thisproductisstableforatleast1yearat

-20oC.Freezeinmultiplealiquotstoavoidrepeatedfreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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