ORDERINGINFORMATION
CatalogNo.CloneNo.MAbSubtypeSizeLibraryPackNo.100ug/clone
13201ELA11-207.2IgM1100ug,500ug132100All4clones
13202ELA11-207.3IgM1100ug,500ug
13203ELA10-101.5IgG12100ug,500ug
13204ELA10-103.2IgG2b2100ug,500ug
1PEG-purifiedantibodyinPBS,pH7.4
2ProteinG-purifiedantibodyinPBS,pH7.4
BACKGROUND
Neutrophilelastaseisamajorneutralproteasepresentinhumanneutrophilsandisreleasedbyneutrophilsfollowingstimulationwithavarietyofstimuli.Itisbelievedtobeamajormediatorofthelungdestructionseeninemphysema.Inadditiontoelastin,neutrophilelastasecancleaveotherBIOLOGicallyactiveproteinssuchasfibrinogenandantithrombinandisreleasedbyneutrophilsduringclotformation.
SPECIFICATIONSUMMARY
Antigen:Purifiedhumanneutrophilelastase.
HostSpecies:Mouse
Specificity:TheseantibodiesrecognizehumanneutrophilelastaseandvaryintheirABIlitytoinhibitneutrophilelastaseactivityasdeterminedinanassayofelastase-mediatedhydrolysisofelastin-CongoRedsubstrate:
CatalogNo. 13201 | %ElastaseInhibition 1.2 |
13202 | 4.1 |
13203 | 90.0 |
13204 | 82.0 |
APPLICATIONS
TheseantibodieshavebeenqualifiedforuseinELISAtodetecthumanneutrophilelastaseandinstudiesofinhibitionandenzymekineticsofhumanneutrophilelastase.
DILUTIONINSTRUCTIONS
DiluteinPBSormediumthatisidenticaltothatusedintheassaysystem.
STORAGEANDSTABILITY
Theseantibodiesarestableforatleastone(1)yearat-20oCto-70oC.Storeproductinappropriatealiquotstoavoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notintendedforuseintherapeuticordiagnosticprocedures.
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