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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
Cataloguenumber
HCV-212
Introduction
HCVisasmall50nm,enveloped,single-stranded,positivesenseRNAvirusinthefamilyFlaviviridae.
HCVhasahighrateofreplicationwithapproximatelyonetrillionparticlesproducedeachdayinaninfectedindividual.DuetolackofproofreADIngbytheHCVRNApolymerase,theHCVhasanexceptionallyhighmutationrate,afactorthatmayhelpiteludethehost"simmuneresponse.HepatitisCvirusisclassifiedintosixgenotypes(1-6)withseveralsubtypeswithineachgenotype.ThepreponderanceanddistributionofHCVgenotypesvariesglobally.Genotypeisclinicallyimportantindeterminingpotentialresponsetointerferon-basedtherapyandtherequireddurationofsuchtherapy.Genotypes1and4arelessresponsivetointerferon-basedtreatmentthanaretheothergenotypes(2,3,5and6).
HCVhasahighrateofreplicationwithapproximatelyonetrillionparticlesproducedeachdayinaninfectedindividual.DuetolackofproofreADIngbytheHCVRNApolymerase,theHCVhasanexceptionallyhighmutationrate,afactorthatmayhelpiteludethehost"simmuneresponse.HepatitisCvirusisclassifiedintosixgenotypes(1-6)withseveralsubtypeswithineachgenotype.ThepreponderanceanddistributionofHCVgenotypesvariesglobally.Genotypeisclinicallyimportantindeterminingpotentialresponsetointerferon-basedtherapyandtherequireddurationofsuchtherapy.Genotypes1and4arelessresponsivetointerferon-basedtreatmentthanaretheothergenotypes(2,3,5and6).
Description
E.coliderivedrecombinantfromHCVsubtype5afusedtoaGSTtag.
Theproteincontainsthefull-lengthHCVNS3(c33c)immunodominantregion.
Theproteincontainsthefull-lengthHCVNS3(c33c)immunodominantregion.
PurificationMethod
HCVNS3Genotype-5aproteinwaspurifiedbyproprietarychromatographictechnique.
Purity
HCVNS3Genotype-5aproteinis>95%pureasdeterminedby10%PAGE(coomassiestaining).
Formulation
25mMTris-HCl,1mMEDTA,1.5Murea&50%glycerol.
StABIlity
HCVNS3Genotype-5aalthoughstableat4°Cfor1week,shouldbestoredbelow-18°C.
Pleasepreventfreezethawcycles.
Specificity
ImmunoreactivewithseraofHCV-infectedindividuals.
Applications
HCVNS3Genotype-5aantigenissuitableforELISAandWesternblots,excellentantigenfordetectionofHCVwithminimalspecificityproblems.
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.


