Type: Goat IgG

Applications: IHC; WB; FC; NB

E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays

Species Reactivity: H

B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All

Format: Affinity Purified - liquid

Immunogen: Purified, NS0-derived, recombinant human Toll-like receptor 4 (rhTLR4; Glu24 - Lys631; Accession # O00206) extracellular domain.

Toll-Like Receptor 4 (TLR4) has been identified next to MD2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram negative bacteria. TLR4 contributes to the initiation of CNS neuroimmune activation after nerve transection. TLR4 is part of an early, specific, innate CNS/microglial response and maybe relevant in the prevention and treatment of neuropathic pain syndromes. TLR4 is weakly expressed by resting cells, but is upregulated following stimulation with LPS.

Image: Toll-Like Receptor 4 (TLR4 or CD284) staining of immersion fixed paraffin-embedded sections of human prostate at 10 µg/mL overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent.  Tissue was stained using the Anti-Goat HRP-DAB. (brown) and counterstained with hematoxylin (blue).

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