Type: Protein

Species Reactivity: H

B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All

AITRL protein , also known as TNFSF18 or Osteostat, is detectable in human microvascular EC and is highly up-regulated by IFN-alpha and IFN-beta.

AITRL inhibits differentiation of osteoclasts from monocytic precursor cells.  It also suppresses the early stage of osteoclastogenesis via inhibition of macrophage colony-stimulating factorinduced receptor activator of NF-kappaB (RANK) expression in the osteoclast precursor cells. It does not inhibit lipopolysaccharide-induced RANK expression in monocytes and dendritic cells, or activation-induced RANK expression in T cells. AITRL is a novel regulator of osteoclast generation and substantiate the major role played by the endothelium in bone physiology.

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