Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllTIE-1(tyrosinekinasewithIgandEGFhomologydomains1)andTIE-2/Tekcompriseareceptortyrosinekinase(RTK)subfamilywithuniquestructuralcharacteristics:twoimmunoglobulin-likedomainsflankingthreeepidermalgrowthfactor(EGF)-likedomainsandfollowedbythreefibronectintypeIII-likerepeatsintheextracellularregionandasplittyrosinekinasedomaininthecytoplasmicregion.ThesereceptorsareexpressedprimarilyonendothelialandhematopoieticProgenitorcellsandplaycriticalrolesinangiogenesis,vasculogenesisandhematopoiesis.
HumanTIE-1CDNAencodesa1124aminoacid(aa)residueprecursorproteinwithan18residueputativesignalpeptide,a727residueextracellulardomainanda354residuecytoplasmicdomain.WhereastwoligandshavebeendescribedforTIE-2[angiopoietin-1(Ang1)andangiopoietin-2(Ang2)],sofarnoligandwasfoundforTIE-1.
