Type:Protein
SpeciesReactivity:M
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllWntsignalingisinvolvedinavarietyofdevelopmentalprocessesincludingcellfatedetermination,cellpolarity,tissuepatterningandcontrolofcellproliferation.MembersoftheFrizzledfamilyofproteinsserveasreceptorsfortheWntsignalingpathway.ThefoundingmemberofthisfamilywasidentifiedinDrosophiliabasedonitsroleintissuepolarityintheadultcuticleandnamedforthedisorganizedappearanceofbristlehairsonthemutant.MouseFrizzled-4(mFrz-4)wasoriginallyclonedinaPCRscreentoidentifyadditionalFrizzledfamilymembersinvertebrates.ThereareninemurineFrizzledgenesand10humanFrizzledgenesidentifiedtodate.ThepredictedstructureofFrizzledproteinsissimilaramongallfamilymembers,containingadivergentN-terminalsignalpeptide,ahighlyconservedextracellularcysteine-richdomain,avariable-lengthlinkerregion,aseven-passtransmembraneregion,andavariable-lengthC-terminaltail.ThemostconservedregionsoftheFrizzledproteinsaretheextracellularcysteine-richdomain(CRD)whichspansapproximately120aminoacid(aa)residuesandcontains10invariantcysteines,andtheseventransmembranedomains.MouseFrizzled-4is537aalongandshows97%and93%aaidentitytohumanandXenopusFrizzled-4,respectively.
