Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
CD40LorCD154isamembraneglycoproteinanddifferentiationantigenexpressedonthesurfaceofT-cells.TheCD40ligandstimulatesB-cellproliferationandsecretionofallimmunoglobulinisotypesinthepresenceofcytokines.CD40ligandhasbeenshowntoinducecytokineproductionandtumoricidalactivityinperipheralbloodmonocytes.ItalsocostimulatesproliferationofactivatedT-cellsandthisisaccompaniedbytheproductionofIFN-gamma,TNF-alpha,andIL2.
Image:CD40Ligand/TRAPStructureandSequence
References:
1.CD154-stimulatedGM-CSFreleasebyvascularsmoothmusclecellselicitsmonocyteactivation-roleinatherogenesis. JMolMed2007Jul10;
2.SerumCD40/CD40LsysteminGraves"diseaseandHashimoto"sthyroiditisrelatedtosolubleFas,FasLandhumoralMarkersofautoimmuneresponse. ImmunolInvest2007;36(3):247-57
3.[CorrelationbetweenCD154(CD40L)expressionandnaive/memoryCD4(+)Tcells.] XiBaoYuFenZiMianYiXueZaZhi2007Jun;23(6):491-4
4.HomocysteinemodulatestheCD40/CD40Lsystem. JAmCollCardiol2007Jun5;49(22):2182-90
5.CD40-CD40LInteractioninImmunityAgainstProtozoanInfections. JBiomedBiotechnol2007;2007(3):59430
6.Cuttingedge:smallmoleculeCD40ligandmimeticspromotecontrolofparasitemiaandenhanceTcellsproducingIFN-gammaduringexperimentalTrypanosomacruziinfection. JImmunol2007Jun1;178(11):6700-4
