Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllImmunogen:GranulocyteColonyStimulatingFactorHumanRecombinantproducedinE.coliisasingle,non-glycosylated,polypeptidechaincontaining175aminoacidsandhavingamolecularmassof18.8KD.
GMCSFisacytokinethatcontrolstheproduction,differentiation,andfunctionofgranulocytesandmacrophages.Theactiveformoftheproteinisfoundextracellularlyasahomodimer.Thisgenehasbeenlocalizedtoaclusterofrelatedgenesatchromosomeregion5q31,whichisknowntobeassociatedwithinterstitialdeletionsinthe5q-syndromeandacutemyelogenousleukemia.Othergenesintheclusterincludethoseencodinginterleukins4,5,and13.
GM-CSFstimulatesthegrowthanddifferentiationofhematopoieticprecursorcellsfromvariouslineages,includinggranulocytes,macrophages,eosinophilsanderythrocytes.
Image: GM-CSF StructureandSequence.
References:
1.Influenceofvaryingdosesofgranulocyte-macrophagecolony-stimulatingfactoronpharmacokineticsandantibody-dependentcellularcytotoxicity. CancerImmunolImmunother2007Aug4.
2.HepatitisBvirusvaccineinlymphoproliferativedisorders:aProspectiverandomizedstudyevaluatingtheefficacyofgranulocyte-macrophagecolonystimulatingfactorasavaccineadjuvant.EurJHaematol2007Jul26.
3.Kineticstudiesofconstitutivehumangranulocyte-macrophagecolonystimulatingfactor(hGM-CSF)expressionincontinuouscultureofPichiapastoris. BiotechnolLett2007Jul25.
4.[Experimentalstudyof131I-labeledgranulocytemacrophagecolony-stimulatingfactorinSCIDmouse-acutemyeloidleukemiamodel] ZhonghuaXueYeXueZaZhi2007Jan;28(1):33-6.
5.Asimplifiedpurificationprocedureforrecombinanthumangranulocytemacrophage-colonystimulatingfactorfromperiplasmicspaceofEscherichiacoli. JChromatogrBAnalytTechnolBiomedLifeSci2007Jun22.
6.Large-ScalePurificationofHumanGranulocyte-MacrophageColony-StimulatingFactorExpressedinBombyxmoriPupae. ApplBiochemBiotechnol2007Apr;141(1):149-60.
