Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
ThisgeneisamemberoftheEPO/TPOfamilyandencodesasecreted,glycosylatedcytokinecomposedoffouralphahelicalbundles.Theproteinisfoundintheplasmaandregulatesredcellproductionbypromotingerythroiddifferentiationandinitiatinghemoglobinsynthesis.Thisproteinalsohasneuroprotectiveactivityagainstavarietyofpotentialbraininjuriesandantiapoptoticfunctionsinseveraltissuetypes.
Image: EPO-αHumanStructureandSequence.
References:
1.EfficacyandtolerABIlityofintravenouscontinuouserythropoietinreceptoractivator:a19-week,phaseII,multicenter,randomized,open-label,dose-findingstudywitha12-monthextensionphaseinpatientswithchronicrenaldisease. ClinTher2007Apr;29(4):626-39.
2.TheefficacyofpreoperativeadmiNISTrationofasingledoseofrecombinanthumanerythropoietininpediatriccardiacsurgery. HeartSurgForum2007;10(2):E115-9.
3.Neurocognitivedysfunctionpost-cardiacsurgeryandtheneuroprotectiveeffectsoferythropoietin. CanJCardiovascNurs2007;17(2):5-8;quiz8-9,5.
4.[Pureredcellaplasiainpatientstreatedwithrecombinanterythropoietinforanemiaduetochronicrenaldisease] RinshoKetsueki2007May;48(5):391-6.
5.Erythropoietin,theFDA,andoncology. NEnglJMed2007Jun14;356(24):2448-51.
6.Docancercellsexpressfunctionalerythropoietinreceptors? NEnglJMed2007Jun14;356(24):2447.
