Neuromics/PDGF - B Human/PR27060-5/5 ug

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¥2160.00
货号:PR27060-5
浏览量:127
品牌:Neuromics
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Type:Protein

 

SpeciesReactivity:H

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Picture
Theterm‘PDGF’referstoafamilyofdisulphidebond-linkeddimericisoformsthatactasautocrineandparacrinegrowthfactorsandareproducedbyavarietyofcelltypesotherthanplatelets.Theyactaspotentmitogensforalmostallmesenchymally-derivedcells.Aberrantexpressionisinvolvedincertaincancers,fibroproliferativedisordersandatherosclerosis.Theproteinalsocontributestowoundhealingandneuralregeneration.TherearefourmembersofthePDGFfamily–PDGFA,PDGFB,PDGFCandPDGFD.TwodistincttypesofPDGF-Aexist–ashortformthatissolubleandalongformthatisretainedbytheextracellularmatrix.

Image: PDGF-B StructureandSequence.

References:

1.Correlationbetweenplatelet-derivedgrowthfactorBchainandboneresorptioninratperiapicallesions. JEndod2007Jun;33(6):709-11.
2.Roleofplatelet-derivedgrowthfactor-B,vascularendothelialgrowthfactor,insulin-likegrowthfactor-II,mitogen-activatedproteinkinaseandtransforminggrowthfactor-beta1inexpansion-inducedlunggrowthinfetalsheep. ReprodFertilDev2006;18(6):655-65.
3.Platelet-derivedgrowthfactorBretentionisessentialfordevelopmentofnormalstructureandfunctionofconduitvesselsandcapillaries. CardiovascRes2006Aug1;71(3):557-65.
4.RequirementofNckadaptorsforactindynamicsandcellmigrationstimulatedbyplatelet-derivedgrowthfactorB. ProcNatlAcadSciUSA2006Jun20;103(25):9536-41.
5.Inhibitionofplatelet-derivedgrowthfactorBsignalingenhancestheefficacyofanti-vascularendothelialgrowthfactortherapyinmultiplemodelsofocularneovascularization. AmJPathol2006Jun;168(6):2036-53.
6.Heparansulphaterequirementinplatelet-derivedgrowthfactorB-mediatedpericyterecruitment. BiochemSocTrans2006Jun;34(Pt3):454-5.

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