Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
ThehumanFGF-9CDNAencodesa208aminoacidresidueproteinthatcontainsasingle,potentialN-linkedglycosylationsite.Thenativeproteinisglycosylatedandisefficientlysecretedaftersynthesis,althoughFGF-9lacksatypicalsecretionsignal.RatandmouseFGF-9showaveryhighhomologytohumanFGF-9.ThetranscriptsforFGF-9havebeenfoundinbrainandinkidneytissue.FibroblastGrowthFactor-9isamemberofthefibroblastgrowthfactor(FGF)family.FGFfamilymemberspossessbroadmitogenicandcellsurvivalactivities,andareinvolvedinavarietyofBIOLOGicalprocesses,includingembryonicdevelopment,cellgrowth,morphogenesis,tissuerepair,tumorgrowthandinvasion.FGF9wasisolatedasasecretedfactorthatexhibitsagrowth-stimulatingeffectonculturedglialcells.Innervoussystem,thisproteinisproducedmainlybyneuronsandmaybeimportantforglialcelldevelopment.ExpressionofthemousehomologofthisgenewasfoundtobedependentonSonichedgehog(Shh)signaling.Micelackingthehomologgenedisplayedamale-to-femalesexreversalphenotype,whichsuggestedaroleintesticularembryogenesisFibroblastGrowthFactor9mayhavearoleinglialcellgrowthanddifferentiationduringdevelopment,gliosisduringrepairandregenerationofbraintissueafterdamage,differentiationandsurvivalofneuronalcells,andgrowthstimulationofglialtumors.
Image:FGF-9proteinstructureandsequence
References:
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