Type:Protein
SpeciesReactivity:M
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFGF-8isamemberofthefibroblastgrowthfactorfamilythatwasoriginallydiscoveredasanandrogen-inducedgrowthfactoressentialfortheandrogen-dependentgrowthofmousemammarycarcinomacells.ThemouseFGF-8primarytranscriptisalternativelysplicedtogenerateatleast8secretedisoformsthatdifferonlyattheiraminoterminis.TheFGF-8isoformsdifferentiallyactivatethevariousalternativelysplicedformsoffibroblastgrowthfactorreceptors1-3,andfibroblastgrowthfactorreceptor4.FGF-8bhasbeenshowntoactivatethe‘c’spliceformofFGFR2,FGFR3,andFGFR4.Duringmousedevelopment,expressionofFGF-8wasrestrictedtoembryonicdays9through13.ThepatternofFGF-8expressionduringmousedevelopmentsuggestsaroleforFGF-8inmultipleregionsofectodermaldifferentiationinthepost-gastrulationmouseembryo.Theseincludearoleinoutgrowthandpatterningoftheface,limbs,andcentralnervoussystemofthevertebrate.TheFGF-8locushasbeenmappedtomousechromosome19andhumanchromosome10.ThehumanFGF-8genehasrecentlybeenclonedandshowntoencodeonly4potentialisoforms.MouseandhumanFGF-8aandFGF-8bisoformsare100%identicalandFGF-8eandFGF-8fisoformsare98%identicalattheproteinsequencelevel.However,humanproteinscorrespondingtothemouseFGF-8c,d,gandhisoformsdonotexist(MacArthur,C.A.etal.,1995,Development121:3603-3613;Crossley,P.H.etal.,1996,Cell 84:127-136;Gemel,J.etal.,1996,Genomics35:253-257).
