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商品描述
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
WWOXisaproapoptoticproteinandatumorsuppressorprotein.Itisfoundinalleukaryotesandinvolvedintheregulationofabroadrangeofcellularfunctionssuchasproteindegradation,transcription,andRNAsplicing.WWOXfunctionssynergisticallywithTP53/p53tocontrolgenotoxicstress-inducedcelldeath.WWOXtakespartintumornecrosisfactor(TNF)-mediatedcelldeath.
LossofWWOXexpressionisassociatedwithpancreatobiliarycancers.ReducedexpressionlevelsofWWOXproteinisassociatedwiththepathogenesisofbasal-likedifferentiationinbreastcancer.LossofWWOXexpressionisassociatedwithextrahepaticcholangiocarcinoma.
Inaddition,proteinlevelsofWWOX,itsTyr33-phosphorylatedform,andWOX2aresignificantlydown-regulatedintheneuronsofAlzheimer"shippocampi.
