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商品描述
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllMicrotubule-AssociatedProteinTau/MAPTisaneuronalmicrotubuleassociatedproteinlocalizedmostlyonaxons.MAPTpromotestubulinpolymerisationandstABIlizesmicrotubules,howeveritalsoservestoconnectcertainsignallingpathwaystotheCytoskeleton.MAPT,initshyperphosphorylatedform,isthemainpartofpairedhelicalfilaments(PHF)andneurofibrillarylesionsinAlzheimer""sdisease(AD)brain.
MAPTRecombinantHumanproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining372aminoacids(1-352a.a.)andhavingamolecularmassof38.9kDa(RealmolecularweightonSDS-PAGEwillbeshiftup).TheMAPTisfusedtoa20aminoacidHis-TagatN-terminusandpurifiedbyproprietarychromatographictechniques.
