Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllEMAP-IIalsocalledSCYE1isatumorderivedcytokinethatplaysaroleinawidevarietyofactivitiesonendothelialcells,monocytesandneutrophils.EMAP-IIinhibitsendothelialcellproliferation,vasculogenesis,neovesselformation,andcaninduceapoptosis.Itisalsochemotactictowardsneutrophilsandmonocytesandinducesmyeloperoxidaseactivityfromneutrophils.EMAP-IIclinicalvalueisinhibitingangiogenesisofvascularbedsandsuppressingthegrowthofprimaryandsecondarytumorswithnoaffecttonormaltissues.SCYE1isspecificallyinducedbyapoptosis,anditisinvolvedinthecontrolofangiogenesis,inflammation,andwoundhealing.ThereleaseofthisSCYE1rendersthetumor-associatedvasculaturesensitivetotumornecrosisfactor.Theprecursorproteinisidenticaltothep43subunit,whichisassociatedwiththemulti-tRNAsynthetasecomplex,anditmodulatesaminoacylationactivityoftRNAsynthetaseinnormalcells.EMAP-2playsaroleininthestimulationofinflammatoryresponsesafterproteolyticcleavageintumorcells.
EMAP-IIRecombinantHumanproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining166aminoacidsandhavingamolecularmassof18.3kDa.TheEMAP-IIispurifiedbyproprietarychromatographictechniques.
