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商品描述
Type:MouseIgG
Applications:IF;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:M;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:Syntheticpeptideaminoacids15-34(CTQPHHGARAMNDIGDYVGS,extracellularN-terminus)ofratGABA-A-R-Delta.
GABAAreceptorsareligand-gatedchloridechannelsthatplayaroleasinhibitoryneurotransmitters.Theyareknowntargetsforcertainclassesofenvironmentalandpharmaceuticalcompounds, becauseanumberofdrugsinteractwithbindingsitesonGABA(A).Someofthesedrugsincludebenzodiazepines,anticonvulsants,andanesthetics.
Image:GABAAReceptor,deltastainingofculturedrathippocampalneuronsurface(S,left)andtotalprotein(T,right)DatacourtesyofSuchitraJoshiandJaideepKapur,UniversityofVirginia.
TheGABA-Areceptorisgenerallypentamericandtherearefivetypesofsubunits:alpha,beta,gamma,delta,andrho.(GenomeRes.16(1):55–65).DefectsinGABAAR,delta (GABRD) geneare associatedAtaxiandGeneralized Epilepsy.
ThisantibodyhasbeendevelopedbyUCDavisunderagrantbyNIH.
