TwotypesofsolubleTNFreceptors(sTNFR-1andsTNFR-2)havebeenidentified,whichacttoneutralizetheBIOLOGicalactivitiesofTNF-alphaandTNF-beta.Levelsofthesesolublereceptorsappeartoariseasaresultofsheddingoftheextracellulardomainsofthemembraneboundreceptors.ElevatedlevelsofsolubleTNFreceptorshavebeenfoundintheamnioticfluidofpregnantwomen.
TherecombinantsTNFR-1comprisesa161aminoacidfragment(41-201)correspondingtothematuresTNFR-1proteinandisexpressedinE.coliwithanamino-terminalhexahistidinetag.
Form:liquid
Purity:95%SDS-PAGE
Storage:Storeat-20°C.