Life Sensors是一家为药物发现和研究市场提供方法和建立可行性技术方法的生物技术公司。该公司为泛素和泛素蛋白酶体通路研究提供创新性的研究工具而占据世界领导地位。其原核和真核蛋白表达系统SUMOpro 和SUMOstar 已被世界范围内的学术、政府研究机构和制药、生物技术公司广泛应用。
部分产品信息如下：
Ubiquitin Affinity Reagents （TUBEs）LifeSensors has developed TUBE （Tandem Ubiquitin Binding Entity） technology for the detection, characterization and isolation of polyubiquitylated proteins from cells and tissue extracts. TUBEs have 100 to 1000-fold higher affinity for polyubiquitin chains compared to monomer ubiquitin binding domains （UBDs）. TUBEs both stabilize and bind to ubiquitylated proteins, serving as an indispensable tool for ubiquitologists.Our versatile collection of TUBEs includes reagents for isolation/pulldown polyubiquitin conjugates （Agarose-TUBEs, GST- and His6-TUBEs）. For immunohistochemistry, use Fluorescent TUBEs conjugated to either fluorescein or TAMRA. Use Biotin-TUBEs for the detection of polyubiquitylated proteins by ligand blotting （“Far Western”）.New Biotin-K63 TUBE 1 （UM304） displays a high sensitivity and specificity for polyubiquitin chains linked through K63. Biotin-K63 TUBE 1 is more sensitive and cost-effective for the detection of K63-linked polyubiquitylated proteins compared to traditional Western blot using chain-specific antibodies. Use Biotin K63-TUBE 1 for ligand blotting, affinity purification from lysates & biological fluids, and in situ detection.
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