• More than 300 labs worldwide have purchased Brefeldin A from LC Labs (either directly from us or from our many distributors, many of whom resell under their own labels).
• Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus. Misumi, Y., et al. \"Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes.\" J. Biol. Chem. 261: 11398-11403 (1986).
• Brefeldin A has been shown to induce apoptosis in human tumor cells via a process requiring caspase activation. Guo, H., et al. \"Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2.\" Exp. Cell Res. 245: 57-68 (1998).
• Brefeldin A has been identified as an activator of the sphingomyelin signal transduction cycle. Linardic, C. M., et al. \"Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking.\" Cell Growth Differ. 7: 765-774 (1996). Alessenko, A.V. \"The role of sphingomyelin cycle metabolites in transduction of signals of cell proliferation, differentiation and death.\" Membr. Cell Biol. 13: 303-320 (2000).
• Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.

Related Terms:

[Decumbin] [Ascotoxin] [Cyanein] [Nectrolide] [Synergisidin] [BFA]M.W. 280.36C16H24O4[20350-15-6]M.I. 11: 1363M.I. 14: 1369

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