- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
Alendronate is a second generation bisphosphonate that exhibits anti-resorptive, anti-inflammatory, immunomodulatory, and anticancer chemotherapeutic activities. Alendronate inhibits bone resorption but does not have any effects on bone mineralization; it also inhibits osteoclast formation and decreases phosphorylation of Akt and ERK1/2 in vitro. In animal models, alendronate decreases production of Th4 and Th17 cytokines and eotaxin-2, suppressing antigen-induced pulmonary immune responses. Additionally, this compound increases δγ T cell activation and inhibits tumor growth in vivo.
Product Info
121268-17-5 |
≥98% |
C4H12NNaO7P2 • 3H2O |
325.08 |
4-Amino-1-hydroxybutylidine-1,1-bisphosphate |
sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate |
Alendronic acid; ABDP |
233-235°C (dec) |
Soluble in water (10 mg/mL). PBS 0.25 mg/mL. DMSO |
White Crystal Powder |
Shipping and Storage
Ambient |
Ambient |
Downloads
A4515 MSDS PDF |
A4515 Info Sheet PDF |
References
Tsubaki M, Komai M, Itoh T, et al. Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation. J Biomed Sci. 2014 Feb 3;21:10. PMID: 24490900.
Sasaki O, Imamura M, Yamazumi Y, et al. Alendronate attenuates eosinophilic airway inflammation associated with suppression of Th4 cytokines, Th17 cytokines, and eotaxin-2. J Immunol. 2013 Sep 15;191(6):2879-89. PMID: 23935198.
Gutman D, Epstein-Barash H, Tsuriel M, et al. Alendronate liposomes for antitumor therapy: activation of γδ T cells and inhibition of tumor growth. Adv Exp Med Biol. 2012;733:165-79. PMID: 22101722.
Takahashi H, Kinbara M, Sato N, et al. Nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice. Int Immunopharmacol. 2011 Oct;11(10):1534-1540. PMID: 21621645.
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