AcidicFibroblastGrowthFactorIntracellular-BindingProtein(FIBP)ishighlyexpressedintheheart,skeletalmuscle,andpancreas.AcidicFibroblastGrowthFactorisamemberofthefibroblastgrowthfactor(FGF)family.FGFfamilymemberspossessbroadmitogenicandcellsurvivalactivities,andareinvolvedinavarietyofBIOLOGicalprocesses,includingembryonicdevelopment,cellgrowth,morphogenesis,tissuerepair,tumorgrowthandinvasion.FIBPisanintracellularproteinthatbindsselectivelytoacidicfibroblastgrowthfactor(aFGF).ItispostulatedthatFIBPmaybeinvolvedinthemitogenicactionofaFGF.
Source | E.coli |
Names | AcidicFibroblastGrowthFactorIntracellular-BindingProtein,aFGFIntracellular-BindingProtein,FGF-1Intracellular-BindingProtein,FIBP |
Accession# | O43427 |
Formulation | Suppliedasa0.2μMfilteredsolutionof50mMTris,pH8.0 |
Shipping | Theproductisshippedondryice/icepacks. |
Storage | Storeat<-20°C,stablefor6monthsafterreceipt. Pleaseminimizefreeze-thawcycles. |
Purity | Greaterthan95%asdeterminedbySEC-HPLCandreducingSDS-PAGE. |
Endotoxin | Lessthan0.1ng/μg(1IEU/μg). |
AminoAcidSequence | AMADIGSMTSELDIFVGNTTLIDEDVYRLWLDGYSVTDAVALRVRSGILEQTGATAAVLQSDTMDHYRTFHMLERLLHAPPKLLHQLIFQIPPSRQALLIERYYAFDEAFVREVLGKKLSKGTKKDLDDISTKTGITLKSCRRQFDNFKRVFKVVEEMRGSLVDNIQQHFLLSDRLARDYAAIVFFANNRFETGKKKLQYLSFGDFAFCAELMIQNWTLGAVDSQMDDMDMDLDKEFLQDLKELKVLVADKDLLDLHKSLVCTALRGKLGVFSEMEANFKNLSRGLVNVAAKLTHNKDVRDLFVDLVEKFVEPCRSDHWPLSDVRFFLNQYSASVHSLDGFRHQALWDRYMGTLRGCLLRLYHD |