| MolecularFormula: | C44H69NO12H2O |
| MolecularWeight: | 822.03g/mol |
| CASNumber: | 109581-93-3 |
| Solubility: | SolubleinDMSOor100%ethanol,methanol,ethylacetateoracetone:insolubleinwater. |
| Purity: | ≥98% |
| Storage: | -20ºC |
| Applications: | Immunosupressivepropertiesverysimilartocyclosporine,buttentoahundredtimesmorepotent |
MaterialSafetyDataSheet
Date:Oct21,2015
1.PRODUCTANDCOMPANYIDENTIFICATION
1.1Productidentifier
Productname:FK-506
CatalogNo:1100060012,1100060052,1100060102
1.2Relevantidentifiedusesofthesubstanceormixtureandusesadvisedagainst
Forresearchuseonly.
1.3Detailsofthesupplierofthesafetydatasheet
Company:EtonBioscienceInc
TollFree:1-800-758-1630
Tel:1-800-758-1630
Fax:1-800-507-2912
1.4Emergencytelephonenumber
1-800-758-1630
2.HAZARDSIDENTIFICATION
2.1Classificationofthesubstanceormixture
AcuteToxicity-Oral,Category3
2.2GHSLabelelements,includingprecautionarystatements
Pictogram
SignalWord | Danger |
HazardStatement | |
H301 | Toxicifswallowed |
Precautionarystatement | |
P264 | Washskinthoroughlyafterhandling |
P302+P310 | IFSWALLOED:immediatelycallaPOISONCENTERordoctor/physician |
P330 | Rinsemouth |
P501 | Disposeofcontents/containertoanapprovedwastedisposalplant |
2.3Otherhazards
None
3.COMPOSITION/INFORMATIONONINGREDIENTS
3.1Substances
MolecularFormula:C44H69NO12H2O
MolecularWeight:822.03g/mol
CASNo:109581-93-3
4.FIRSTAIDMEASURES
4.1Descriptionoffirstaidmeasures
Eyecontact
Checkforandremovecontactlensesandflushwithcopiousamountsofwater;assureadequateflushingbyseparatingtheeyelidswithfingers;callaphysician
SkinContact
Flushwithcopiousamountsofwater;removecontaminatedclothingandshoes;callaphysician
Inhalation
Ifinhaled,removetofreshair;ifbreathingisdifficult,giveoxygen;ifbreathingstops,giveartificialrespiration
Ingestion
Ifswallowed,washoutmouthwithcopiousamountsofwater;callaphysician
4.2Mostimportantsymptomsandeffects,bothacuteanddelayed
Noinformationavailable
4.3Indicationofanyimmediatemedicalattentionandspecialtreatmentneeded.
Noinformationavailable
5.FIREFIGHTINGMEASURES
5.1Extinguishingmedia
Suitableextinguishingmedia
Waterspray,carbondioxide,drychemicalpowderorfoam
5.2Specialhazardsarisingfromthesubstanceormixture
Noinformationavailable
5.3Adviceforfirefighters
Wearself-containedbreathingapparatusandprotectiveclothingtopreventcontactwithskinandeyes.
6.ACCIDENTALRELEASEMEASURES
6.1Personalprecautions,protectiveequipmentandemergencyprocedures
Usefullpersonalprotectiveequipment.Evacuatepersonneltosafeareas.
6.2Environmentalprecautions
Preventfurtherleakageorspillage.Preventproductfromenteringdrain.
6.3Methodsandmaterialforcontainmentandcleaningup
Absorbsolutionswithfinely-powderedliquid-bindingmaterial(diatomite,universalbinders);decontaminatesurfacesandequipmentbyscrubbingwithalcohol;disposeofcontaminatedmaterialaccordingtoSection13
7.HANDLINGANDSTORAGE
7.1Precautionsforsafehandling
Avoidskin/eyecontact.Useprotectiveequipmentasneeded.Washcontaminatedclothingbeforereuse.
7.2Conditionsforsafestorage,includinganyincompatibilities
Keepcontainertightlyclosedinacool,well-ventedplace.Storeat-20˚C.
7.3Specificenduse(s)
Nodataavailable.
8.EXPOSURECONTROLS/PERSONALINFORMATION
8.1ControlParameters
Thisproductcontainsnohazardousmaterialswithoccupationalexposurelimits.
8.2Exposurecontrols
Engineeringcontrols
Provideshowerandeyewashstation
Personalprotectiveequipment
EyeProtection | Wearsafetygoggles |
SkinProtection | Wearprotectiveclothing |
HandProtection | Wearprotectivegloves |
Respiratoryprotection | WearNIOSH/MSHAapprovedrespirators |
9.PHYSICALANDCHEMICALPROPERTIES
9.1Informationonbasicphysicalandchemicalproperties
Appearance | Solid |
pH | Nodataavailable |
Meltingpoint | Nodataavailable |
Freezingpoint | Nodataavailable |
Boilingpoint | Nodataavailable |
Density | Nodataavailable |
Watersolubility | Insoluble |
9.2Othersafetyinformation
Nodataavailable.
10.STABILITYANDREACTIVITY
10.1Reactivity
Nodataavailable
10.2Chemicalstability
Stableunderrecommendedstorageconditions.
10.3Possibilityofhazardousreactions
Nodataavailable.
10.4Conditionstoavoid
Protectfromlightandheat
10.5IncompatIBLematerials
Strongoxidizingagents
10.6Hazardousdecompositionproducts
Thermaldecompositionmayproducetoxicgasessuchascarbonmonoxide,carbondioxide,andnitrogenoxides
11.TOXICOLOGICALINFORMATION
11.1Informationontoxicologicaleffects
Toxicologicaleffectsonthisproducthavenotbeenthoroughlystudied.
12.ECOLOGICALINFORMATION
12.1Toxicity
Avoidreleaseintoenvironment
12.2Persistenceanddegradability
Nodataavailable
12.3.Bioaccumulativepotential
Nodataavailable
12.4Mobilityinsoil
Nodataavailable
12.5ResultsofPBTandvPvBassessment
Nodataavailable
12.6Otheradverseeffects
Nodataavailable
13.DISPOSALINFORMATION
13.1Wastetreatmentmethods
Disposeinaccordancewithlocal,state,andfederalregulations.
14.TRANSPORTINFORMATION
DOT:
UNnumber:2811Class:6.1,Packinggroup:III
Propershippingname:Toxicsolids,organic,n.o.s(FK506)
Marinpollutant:No
PoisonInhalationHazard:No
IATA:
UNnumber:2811Class:6.1,Packinggroup:III
Propershippingname:Toxicsolids,organic,n.o.s(FK506)
IMDG
UNnumber:2811Class:6.1,Packinggroup:III
EMS-No:F-A,S-A
Propershippingname:TOXICSOLID,ORGANIC,N.O.S(FK506)
Marinepollutant:No
15.REGULATORYINFORMATION
EURiskandSafetyphrases:
R25:Toxicifswallowed
S22:Donotbreathedust
S24/25:Avoidcontactwithskinandeyes
S36/37/39:Wearsuitableprotectiveclothing,glovesandeye/faceprotection
16.OTHERINFORMATION
Theinformationaboveisbelievedtobeaccurateandrepresentsthebestinformationcurrentlyavailabletous.However,wemakenowarrantyofmerchantabilityoranyotherwarranty,expressorimplied,withrespecttosuchinformation.EtonBioscienceInc.shallnotbeheldliableforanydamagesorotherconsequencesresultingfromhandlingorfromcontactwiththeaboveproduct.JohnH.Boyd,MaziarDivangahi,LindaYahiaoui,DusankaGvozdic,SalmanQureshi,andBasilJ.Petrof.MOLECULARPATHOGENESIS:Toll-LikeReceptorsDifferentiallyRegulateCCandCXCChemokinesinSkeletalMuscleviaNF-kappaBandCalcineurinInfect.Immun.,Dec2006;74:6829-6838.
