Product overview

• NamePKA inhibitor fragment (6-22) amide
• Short descriptionPotent PKA inhibitor
• Biological descriptionPotent protein kinase A (PKA) inhibitor (K_i = 1.6 nM). Decreases long-term potentiation (LTP) at hippocampal synapses. Reverses morphine tolerance.
• Biological actionInhibitor
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Properties

• Molecular Weight1868.08
• Molecular FormulaC₈₀H₁₃₀N₂₈O₂₄
• CAS Number121932-06-7

Storing and Using Your Product

• Storage instructions-20°C (desiccate)
• Solubility overviewsoluble in acetonitrile
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for PKA inhibitor fragment (6-22) amide

• Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. Inhibition of cAMP-dependent protein kinase.

  Glass DB et al (1989)J Biol Chem 264(24) : 14579-84. PubMedID: 2760075

• Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses.

  Otmakhova NA et al (2000)J Neurosci 20(12) : 4446-51. PubMedID: 10844013

• Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI).

  Dalton GD et al (2005)Neuropharmacology 48(5) : 648-57. PubMedID: 15814100

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