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蚂蚁淘在线 / 品牌中心 / Biosensis / Biosensis/Mouse p75NTR Nerve Growth Factor Receptor-Fc Chimera expressed in mammalian cells/PE-1704-25/25 µg
商品描述
| Description | Nervegrowthfactor(NGF)receptor,alsoknownasp75NTR,isalowaffinityNGFreceptor.ItbindswithequalaffinityallmembersoftheneurotrophinfamilyincludingbetaNGF,BDNF,NT-3andNT-4/5.Italsobindsthepro-neurotrophins.NGFreceptorsmediatesignalingofneurotrophinsforneuronalsurvival,apoptosis,neuriteoutgrowthandsynapticplasticity.ThesereceptorsarealsothoughttoplayaroleinneurogenerativediseasessuchasAlzheimersdisease.Thep75NTRNGFreceptorisatypeItransmembraneglycoprotein(396aa)consistingofasignalpeptide(21aa),anextracellulardomain(225aa)whichcontainsfourcysteinerichdomainsresponsIBLeforligandbinding,atransmembranedomain(19aa)andacytoplasmicdomain(152aa).ItisamemberoftheTNF-alphareceptorfamily(TNR16).Recently,p75NTRhasbeenshowntoactasareceptorformanypathogenssuchasprions,rABIesvirusandamyloidbeta.Italsoactsasaco-receptorforNOGO,mediatinginhibitorysignalsofmyelinassociatedprotein. |
| BatchNo. | Seeproductlabel |
| Unitsize | 25µg |
| OtherNames | Low-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR;p75NTR;CD271;FastNGFreceptor. |
| Accession | Q9Z0W1TNR16_MOUSE; |
| Producedin | Mammalian(CHO)cells.ADNAsequenceencodingthesignalpeptideandextracellulardomainofhumanNGFreceptor(aminoacids1-224)wasfusedtotheFcregionofhumanIgG1(aminoacids104-330).ThechimericproteinwasexpressedinmodifiedCHOcells.Thefullsequenceisavailableonrequestfrombiospeak@Biosensis.com. |
| MolecularWeight | TheNGFReceptor-Fcchimeramigratesasabroadbandbetween65and115kDainSDS-PAGEduetopost-translationalmodifications,inparticularglycosylation.TheunmodifiedNGFReceptor-Fcchimerahasapredictedmassof49.7kDa.TheunmodifiedNGFReceptor-FcchimerahasapredictedpIof4.92. |
| Purity | >95%,asdeterminedbySDS-PAGE. |
| Form | Freeze-dried. |
| Reconstitution | Itisrecommendedthat0.25mlofsterilephosphate-bufferedsaline(PBS)beaddedtothevial. |
| Storage | Lyophilizedproductsshouldbestoredat2-8°C.Followingreconstitution,short-termstorageat4°Cisrecommendedandlonger-termstorageofaliquotsat-18to-20°C.Repeatedfreezethawingisnotrecommended. |
