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蚂蚁淘在线 / 品牌中心 / Biosensis / Biosensis/Human TrkC-Fc Chimera expressed in mammalian cells/PE-1236-50/50 µg
商品描述
| Description | TrkCisamemberofthetropomyosin-relatedkinasereceptorfamily.TrkCisamembrane-boundreceptorthatuponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.TrkCisthereceptorforneurotrophin-3(NT-3).SignallingthroughTrkCleadstocelldifferentiationandmayplayaroleinthedevelopmentofproprioceptiveneuronsthatsensebodyposition.TrkCisaheavilyglycosylatedmoleculewith13potentialN-linkedglycosylationsiteswithintheextracellulardomain. |
| BatchNo. | Seeproductlabel |
| Unitsize | 50µg |
| OtherNames | Tropomyosin-relatedkinasereceptor;NT-3growthfactorreceptor;Neurotrophictyrosinekinasereceptortype3;TrkCtyrosinekinase;GP145-TrkC;Trk-C;NTRK3;TRKC;TrkC-FcChimera |
| Accession | Q16288NTRK3_HUMAN; |
| Producedin | Human-ADNAsequenceencodingthesignalpeptideandextracellulardomainofhumanTrkC(aminoacids1-428)wasfusedtotheFcregionofhumanIgG1(aminoacids93-330).Thechimericproteinwasexpressedinmodifiedhuman293cells. |
| MolecularWeight | TheTrkC-Fcchimeramigratesasabroadbandbetween85and150kDainSDS-PAGEduetopost-translationalmodifications,inparticularglycosylation.TheunmodifiedTrkCFcchimerahasapredictedmolecularmassof71.9kDa.TheTrkC-FcchimeraseparatesintoanumberofisoformswithapIbetween4and7in2DPAGE.TheunmodifiedTrkCFcchimerahasapredictedpIof5.8. |
| Purity | >95%,asdeterminedbySDS-PAGEandvisualizedbysilverstain. |
| Form | TheTrkC-Fcchimeraconsistsof15-55%carbohydratebyweight.Whenreconstitutedin0.5mlsterilephosphate-bufferedsaline,thesolutionwillcontain1%humanserumalbumin(HSA)and10%trehalose. |
| Reconstitution | Itisrecommendedthat0.5mlofsterilephosphate-bufferedsalinebeaddedtothevial. |
| Storage | Lyophilizedproductsshouldbestoredat2to8°C.Followingreconstitutionshort-termstorageat4°Cisrecommended,andlonger-termstorageofaliquotsat-18to-20°C.Repeatedfreezethawingisnotrecommended. |
