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蚂蚁淘在线 / 品牌中心 / Biosensis / Biosensis/Human Stem Cell Factor Receptor-Fc Chimera expressed in mammalian cells/PE-1244-50/50 µg
商品描述
| Description | StemCellFactorReceptor(SCFR)isamemberofthereceptortyrosinekinasefamily.BindingofSCFRtoitsligandStemCellFactor(PE-2008-5)inducesreceptordimerization,autophosphorylationandsignaltransduction.SCFRisessentialforthedevelopmentofnormalhematopoieticcellsandplaysanimportantroleinthesurvival,proliferationanddifferentiationofmastcells,melanocytesandgermcells. |
| BatchNo. | Seeproductlabel |
| Unitsize | 50µg |
| OtherNames | Mast/stemcellgrowthfactorreceptor;SCFR;Proto-oncogenetyrosine-proteinkinaseKit;c-kit;CD117 |
| Accession | P10721KIT_HUMAN; |
| Producedin | Human-ADNAsequenceencodingthesignalpeptideandextracellulardomainofhumanStemCellFactorReceptor(aminoacids1-520)wasfusedtotheFcregionofhumanIgG1(aminoacids93-330).Thechimericproteinwasexpressedinmodifiedhuman293cells. |
| MolecularWeight | TheSCFR-FcChimeramigratesasabroadbandbetween90and150kDainSDS-PAGEduetopost-translationalmodifications.ThiscompareswiththeunmodifiedSCFR-FcChimerathathasapredictedmolecularmassof83.1kDa.TheChimeraseparatesintoanumberofisoformswithapIbetween4.5and8in2DPAGEduetopost-translationalmodifications.TheunmodifiedSCFRFcChimerahasapredictedpIof6.6. |
| Purity | >95%,asdeterminedbySDS-PAGEandvisualizedbysilverstain |
| Biol.activity | TheED50oftheSCFR-FcChimeraistypically1-3ug/mlasmeasuredbyitsABIlitytoneutralizeSCFmediatedproliferationusingthehumangrowthfactordependentM-07ecellline. |
| Form | TheSCFR-FcChimeraconsistsof5-45%carbohydratebyweight.Whenreconstitutedin0.5mlsterilephosphate-bufferedsaline,thesolutionwillcontain1%humanserumalbumin(HSA)and10%trehalose. |
| Reconstitution | Itisrecommendedthat0.5mlofsterilephosphate-bufferedsalinebeaddedtothevial. |
| Storage | Lyophilizedproductsshouldbestoredat2to8°C.Followingreconstitutionshort-termstorageat4°Cisrecommended,andlonger-termstorageofaliquotsat-18to-20°C.Repeatedfreezethawingisnotrecommended. |
