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蚂蚁淘在线 / 品牌中心 / Biosensis / Biosensis/Human Nerve Growth Factor Receptor-Fc Chimera (209 amino acids) expressed in mammalian cells/PE-1237-25/25 µg
商品描述
| Description | Nervegrowthfactor(NGF)receptor,alsoknownasp75NTR, isalowaffinityNGFreceptor.ItbindswithequalaffinityneurotrophinssuchasbetaNGF,BDNF,NT-3andNT-4.NGFreceptorsmediatesignalingofneurotrophinsforneuronalsurvival,apoptosis,neuriteoutgrowthandsynapticplasticity.ThesereceptorsarealsothoughttoplayaroleinneurogenerativediseasessuchasAlzheimersdisease.TheNGFreceptorisatypeItransmembraneglycoprotein(399aa)consistingofasignalpeptide(28aa),anextracellulardomain(222aa)whichcontainsfourcysteinerichdomainsresponsIBLeforligandbinding,atransmembranedomain(22aa)andacytoplasmicdomain(155aa). |
| BatchNo. | Seeproductlabel |
| Unitsize | 25µg |
| OtherNames | Low-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR;p75NTR;CD271; |
| Accession | P08138TNR16_HUMAN; |
| Producedin | Human-ADNAsequenceencodingthesignalpeptideandextracellulardomainofhumanNGFreceptor(aminoacids1-237)wasfusedtotheFcregionofhumanIgG1(aminoacids93-330).Thechimericproteinwasexpressedinmodifiedhuman293cells. |
| MolecularWeight | TheNGFReceptor-Fcchimeramigratesasabroadbandbetween65and90kDainSDS-PAGEduetopost-translationalmodifications,inparticularglycosylation.TheunmodifiedNGFReceptor-Fcchimerahasapredictedmassof49.2kDa.TheNGFReceptor-FcchimeraseparatesintoanumberofisoformswithapIbetween4.2and5.3in2DPAGE.TheunmodifiedNGFReceptor-FcchimerahasapredictedpIof4.89. |
| Purity | >95%,asdeterminedbySDS-PAGEandvisualizedbysilverstain |
| Form | TheNGFReceptor-Fcchimeraconsistsof25-45%carbohydratebyweight. |
| Reconstitution | Itisrecommendedthat0.5mlofsterilephosphate-bufferedsaline(PBS)beaddedtothevial.Whenreconstitutedin0.5mlofPBS,thesolutionwillcontain1%humanserumalbumin(HSA)and10%trehalose. |
| Storage | Lyophilizedproductsshouldbestoredat2-8°C.Followingreconstitution,short-termstorageat4°Cisrecommendedandlonger-termstorageofaliquotsat-18to-20°C.Repeatedfreezethawingisnotrecommended. |
