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蚂蚁淘在线 / 品牌中心 / Biosensis / Biosensis/Rabbit polyclonal to mouse Interleukin 1beta (IL-1beta) Affinity purified/R-1658-100/100 ug
商品描述
| Description | Interleukin-1beta(IL-1β)alsoknowascatabolin,isacytokineproteinthatinhumansisencodedbytheIL1Bgene,whichlocalizestothelongarmofchromosome2.Interleukin1wasdiscoveredbyGeryin1972.Henameditlymphocyte-activatingfactor(LAF)becauseitwasalymphocytemitogen.Itwasnotuntil1985thatinterleukin1wasdiscoveredtoconsistoftwodistinctproteins,nowcalledinterleukin-1alphaandinterleukin-1beta.IL-1βisamemberoftheinterleukin1cytokinefamily.Thiscytokineisproducedbyactivatedmacrophagesasaproprotein,whichisproteolyticallyprocessedtoitsactiveformbycaspase1(CASP1/ICE).Thiscytokineisanimportantmediatoroftheinflammatoryresponse,andisinvolvedinavarietyofcellularactivities,includingcellproliferation,differentiation,andapoptosis.Theinductionofcyclooxygenase-2(PTGS2/COX2)bythiscytokineinthecentralnervoussystem(CNS)isfoundtocontributetoinflammatorypainhypersensitivity.Reference:http://en.wikipedia.org/wiki/IL1B BiosensisrabbitpolyclonaltomouseIL-1βhasbeentestedagainstmousetissuelysatesandreactswellinwesternblots.Otherapplicationsandotherspecieshavenotyetbeentested. |
| BatchNo. | seeviallabel |
| Unitsize | 100ug |
| Antigen | Aminoacids250-265aa,(FLGNNSGQDIIDFTME)frommouseIL-betaprotein |
| Sequence | FLGNNSGQDIIDFTME |
| AntigenLocation | C-terminus |
| AntigenLength | 15aminoacids |
| AntibodyType | RabbitIgG |
| Isotype | IgG |
| Accession | P10749Here |
| Producedin | Rabbit |
| CompoundName | Interleukin1beta,IL-1beta |
| Purity | 100ugofaffinitypurifiedrabbitIgGin5mgBSA,0.9mgNaCl,0.2mgNa2HPO4,0.05mgThimerosal,0.05mgNaN3buffer. |
| Applications | Westernblot0.5-1.0ug/mL;detectsabandat~17kDaforthematuremouseform.Insomeinstancestheproformat~30kDacanalsobedetected.Thisantibodydoesnotfunctionforimmunohistochemistry. |
| Specificity | Mouse,otherspeciesnotyettested.Theantibodymayalsoreactwithratduetosequencehomology. |
| SpeciesAgainst | Mouse |
| AntibodyAgainst | Mouse |
| Cross-reactivity | Otherspeciesnotyettested |
| Form | affinitypurified |
| Appearance | lyophilized |
| Reconstitution | Reconstitutewith200uLofdistilledwater,finalconcentration0.5mg/mL |
| Storage | At2-8degCforoneyear(lyophilized).Afterreconstitutionaliquotandstorefrozenat-20degCforuptosixmonths.Avoidrepeatedfreezingandthawing. |
