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蚂蚁淘在线 / 品牌中心 / Biosensis / Biosensis/Human Stem Cell Factor receptor protein expressed in mammalian cells/PE-1243-50/50 µg
商品描述
| Description | StemCellFactorReceptor(SCFR)isamemberofthereceptortyrosinekinasefamily.BindingofSCFRtoitsligandStemCellFactor(PE-1242-5)inducesreceptordimerization,autophosphorylationandsignaltransduction.SCFRisessentialforthedevelopmentofnormalhematopoieticcellsandplaysanimportantroleinthesurvival,proliferationanddifferentiationofmastcells,melanocytesandgermcells. |
| BatchNo. | Seeproductlabel |
| Unitsize | 50µg |
| OtherNames | Mast/stemcellgrowthfactorreceptor;SCFR;Proto-oncogenetyrosine-proteinkinaseKit;c-kit;CD117 |
| Accession | P10721KIT_HUMAN; |
| Producedin | Human-ADNAsequenceencodingthesignalpeptideandextracellulardomainofhumanStemCellFactorReceptor(aminoacids1-520)wasexpressedinmodifiedhuman293cells. |
| MolecularWeight | UnderreducingconditionsSCFRmigratesasabroadbandbetween65and100kDaonSDS-PAGEduetopost-translationalmodifications.TheunmodifiedSCFRpolypeptidehasapredictedmonomericmolecularmassof55.9kDa.SCFRseparatesintoanumberofglycoformswithapIbetween4and7on2DPAGEduetopost-translationalmodifications.TheunmodifiedSCFRhasapredictedpIof6.1. |
| Purity | >95%,asdeterminedbySDS-PAGE,visualisedbyCoomassieBrilliantBlue |
| Biol.activity | TheED50ofSCFRistypically2-4ug/mlfromitsABIlitytoneutraliseSCFmediatedproliferationofthehumangrowthdependentM-07ecellline. |
| Form | PurifiedSCFRconsistsofapproximately15-45%carbohydratebyweight.Whenreconstitutedin0.5mlsterilephosphate-bufferedsaline,thesolutionwillcontain1%humanserumalbumin(HSA)and10%trehalose. |
| Reconstitution | Itisrecommendedthat0.5mlofsterilephosphate-bufferedsalinebeaddedtothevial. |
| Storage | Lyophilizedproductsshouldbestoredat2to8°C.Followingreconstitution,short-termstorageat4°Candlonger-termstorageofaliquotsat-18to-20°Cisrecommended.Repeatedfreezethawingisnotrecommended. |
