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商品描述
| Description | Saporinisaribosome-inactivatingprotein(RIP)oftypeI.ThismonomericRNAN-glycosidasepurifiedfromseedsoftheplantSaponariaofficinalisalsoknownasSoapwort,iscapableofspecificdepurinationofeukaryoticribosomesthusarrestingproteinsynthesis.NoligandhasbeenidentifiedinsaporinhenceitsinABIlitytotransversethecellmembrane.Duetoitstoxicityandstabilityofthestructure,saporinhasprovenextremelyusefulforconstructionofimmunotoxins. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| OtherNames | Saponariaofficinalis;Commonsoapwort;ribosomeinactivatingproteinsaporin-6;SAP-6;SO-6;rRNAN-glycosidase |
| Accession | RIP6_SAPOF |
| Producedin | PurifiedfromseedsoftheplantSaponariaofficinalis. |
| MolecularWeight | 29.5kDa |
| Handling | Onlyqualifiedpersonnelshouldhandlethisproduct.Extremeprecautionmustbeemployedwhenhandlingthetoxin.Wearlabcoat,glovesandsafetyglasses.Thetoxinmustnotcomeintocontactwithopenwounds.Practicegoodlaboratorytechniquetoavoidauto-exposure/auto-injection!Washthoroughlyanypartofthebodyexposedtothetoxin.Contaminatedmaterialsshouldbeexposedto300mMNaOHorautoclaved. |
| Purity | 95%bySDS-PAGEandWesternBlot. |
| Biol.activity | Uponintroductionintothecells,saporinwillarresttheproteinsynthesisbydamagingtheribosmes. |
| Form | Lyophilised |
| Reconstitution | SaporinmaybereconstitutedinthebufferofchoiceforexamplePBS. |
| Storage | Aliquotandkeepat-20ºCforlong-termstorage.Forshorttermkeepat4ºC.Avoidrepetitivefreeze/thawcycles. |
| References | Stirpe,F.etal(1983)BiochemJ216,617-625 |
