Description

ARTC2, also known as ART2.2, is a 35 kD, GPI-anchored, and cell surface ADP-ribosyltransferase that is highly expressed by regulatory T cells (Tregs) and natural killer T (NKT) cells. ARTC2 is enzymatically active at 4°C. Through the ribosylation of the ion channel P2X7, ARTC2 mediates NAD⁺-induced cell death (NICD) and the proteolytic shedding of CD27 and CD62L. Blocking the activity ARTC2 with Treg-Protector™ improves the recovery of Tregs and NKT cells during their isolation from lymphatic and peripheral tissues.

Product Details  Biolegend揭示出对神经系统以及影响神经系统的疾病的更好理解的研究可以转化为改善数百万生命的治疗方法。BioLegend提供广泛的产品组合，为您的神经科学实验提供解决方案，包括抗体，免疫测定溶液，重组蛋白，磁性细胞分离和单细胞蛋白质组学试剂。我们的试剂是与该领域的杰出领导者（如迈克尔·J·福克斯基金会）合作建造的（请参见下面的“产品亮点”标签），这表明我们承诺与您的团队合作寻找新发现，为我们的客户带来新的选择和全面的解决方案研究神经系统疾病的解决方案。